Santiago de Cali, or Cali, is the capital of the Valle del Cauca department, and the most populous city in southwest Colombia, with 2,280,522 re…Santiago de Cali, or Cali, is the capital of the Valle del Cauca department, and the most populous city in southwest Colombia, with 2,280,522 residents estimate by DANE in 2023. The city spans 560.3 km² with 120.9 km² of urban area, making Cali the second-largest city in the country by area and the third most populous. As the only major Colombian city with access to the Pacific Coast, Cali is the main urban and economic center in the south of the country, and has one of Colombia's fastest-growing economies. The city was founded on 25 July 1536 by the Spanish explorer Sebastián de Belalcázar.
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