With both fighters being deceptively difficult to kill, their first encounter back at UFC 297 ended up being a tactical, back-and-forth battle that saw Du Plessis narrowly scrape out a split decision win on the scorecards to become the new champion at 185 pounds.

This is the second title defense for the 31-year-old Du Plessis (22-2), a -210 favorite at BetMGM Sportsbook. He defeated Israel Adesanya with a fourth-round submission Aug. 17 in Perth, Australia.

UFC 312 is headlined by a rematch for the Middleweight title. Check the UFC odds series for our Du Plessis-Strickland prediction and pick.