Hirschsprung disease (HSCR) is the third most common congenital disorder of the gastrointestinal tract. This study aims to elucidate changes in protein expression between the normal and aganglionic ...

A manometric technic is described for the diagnosis of Hirschsprung's disease without the necessity of deep-muscle rectal biopsy. Separate pressure recordings were obtained from the internal and ...

Despite removing the aganglionic segment, however, complications of the disease are common, with at least 50% of patients suffering from severe constipation, diarrhea, fecal incontinence, or ...

THE diagnosis of Hirschsprung's disease is not always easy. The patient presenting a typical history of chronic constipation, with physical signs of a distended abdomen and an empty rectal ampulla, ...