CAR T cell therapy targets key mutation driving rare blood cancers

A new form of CAR T-cell therapy has been designed to find and destroy the cancer-driving stem cells responsible for a group ...
Seeking Alpha

Damora Therapeutics: Well-Funded Moonshot For CALR Mutations

Damora Therapeutics is focused on mutant-CALR blood diseases, with DMR-001 as its lead asset. They have approximately $562.3 million in cash, and management believes this gives them enough runway into ...
Nasdaq

Positive Late-Breaking Data for Incyte’s First-in-Class mutCALR-targeted therapy INCA033989 in Essential Thrombocythemia Presented at EHA2025

WILMINGTON, Del.--(BUSINESS WIRE)-- Incyte (Nasdaq:INCY) today announced the first clinical data from two studies evaluating the safety, tolerability and efficacy of INCA033989, a novel, first in ...
BioWorld

Incyte’s anti-CALR displays robust antimyeloproliferative effect

Among the acquired mutations in the calreticulin (CALR) gene, both 52 bp deletion (del52) and 5 bp insertion (ins5) are among the most frequent and are linked to two different types of ...
Rutland Herald

Incyte Announces New Positive Data at EHA 2026 Showed INCA033989 Achieved Rapid, Robust and Sustained Clinical and Molecular Responses and Was Well Tolerated in Patients with ...

Incyte (Nasdaq:INCY) today announced updated clinical data from two Phase 1 studies evaluating the safety, tolerability and efficacy of INCA033989, a first-in-class mutant calreticulin ...
The American Journal of Managed Care

Lack of Mutations Associated With Favorable Prognosis in MPN-U

While the Dynamic International Prognostic Scoring System and bone marrow blasts may predict overall survival, the lack of certain mutations is also associated with a better prognosis for ...
Cure Today

Jakafi May Not Associate with Long-Term Benefits in Myelofibrosis Subset

CALR-mutated myelofibrosis patients often present with more severe disease and require more innovative therapies for better long-term outcomes. Jakafi shows initial benefits, but CALR-mutated patients ...