Downstream bioprocessing steps have long been a challenge to drug manufacturers, particularly the chromatography step for purification of monoclonal antibodies (mAbs). The complexity of traditional ...

Chromatography is a technique that is used for separation of mixtures. The name combines the Greek word chroma, or “color,” with graphein, “to write.” The technique was invented in 1900 by Mikhail ...

Reviewed by Dr. Catherine Shaffer, Ph.D. Chromatography (from the Greek words chroma, "color," and graphein, "to write") is a method for the separation of a mixture. In simple terms, the process ...

The influence of particle and pore size has been recognized since the publication of the first theories of chromatography. Ideally, and in very general terms, a process should maximize the contact ...

Advanced analytics and modeling can be used to predict downstream failures, allowing for corrective action before batches are lost. In the biopharmaceutical industry, quality and consistency are two ...

ASK A DOZEN CHEMISTS about the forces that drive innovation in high-performance liquid chromatography, and nearly all of them will agree: When it comes to chemical separations, the name of the game is ...

Simulated moving bed chromatography uses a counter-current to allow continuous chromatographic separations, which allows researchers to extract more analyte whilst using less packing material and ...