By these arrangements, each of the two arms of the antibody includes one light chain and one heavy chain, with the variable regions at the tips of the Y arms defining antigen specificity.

fully human heavy chain-only antibodies that are approximately half the size of conventional IgGs, offering significant advantages for next-generation antibody therapies. With a clinically ...

The antibody molecule in particular has been ... the reassembly of naturally occurring genes encoding the heavy- and light-chain domains from either immune 1,2 or nonimmune B-cell sources 3 ...