Fluorescent image of PIEZO1 in native cell membrane (left) and an artistic representation of its conformational states resolved with Ångström precision (right). Our remarkable ability to perform ...

Current optical and electron microscopy imaging techniques are not suited for measuring the dynamic characteristics of living microorganisms at tiny scales due to complex sample preparation methods or ...

Cryogenic optical microscopy uncovers multiple conformations of PIEZO1 in cell membranes, offering atomic-scale insights into how cells sense force. The team focused on PIEZO1, a mechanosensitive ion ...

Microscopy continues to transform the life sciences. Here are five recent breakthroughs made possible by the technique.

Cell membranes play a crucial role in maintaining the integrity and functionality of cells. However, the mechanisms by which they perform these roles are not yet fully understood. Scientists from the ...

Collaboration between researchers at the University of Geneva, Institut de biologie structurale de Grenoble, and the University of Fribourg has shown how lipids and proteins in cell membranes react in ...

For Amy Engevik, an epithelial cell biologist at the Medical University of South Carolina who studies cell function in the gastrointestinal tract, protein location matters more than abundance. She ...

Cells do more than carry out chemical reactions. New theoretical work suggests they may also generate usable electrical ...

Electron microscopy has become a vital tool in structural biology, enabling researchers to visualize biological macromolecules at near-atomic resolution. Recent advances have transformed it from a low ...