After treatment, the mice’s memories were essentially shunted back into a younger state. The researchers found that reprogrammed engrams displayed molecular behavior of more youthful cells. Using a ...

Memories are thought to be stored in sparse groups of neurons called engrams. These are the cells that switch on during learning and can later switch on again during recall. In physiological aging and ...

Our experiences leave traces in the brain, stored in small groups of cells called engrams. Engrams are thought to hold the information of a memory and are reactivated when we remember, which makes ...

Age-related memory decline and neurodegenerative diseases like Alzheimer's are often thought of as irreversible. But the brain is not static; neurons continually adjust the strength of their ...

Age-related memory decline and neurodegenerative diseases like Alzheimer's are often thought of as irreversible.

The hippocampus, a small seahorse-shaped structure buried deep in the temporal lobe, acts as the brain’s primary gateway for converting fleeting experiences into stable, retrievable memories. What ...

Infantile amnesia is the global loss of episodic and contextual memories formed in early life. Our research shows that the engrams storing these memories endure in the brain into adulthood (in mice), ...

Babies of every species from mouse to human rapidly forget things that happen to them-an effect called infantile amnesia. A type of brain immune cell called microglia might control this type of ...

Schematic model showing how memory is consolidated in the prefrontal cortex and how circuitry through the amygdala shifts as hippocampal engram cells become silent and cortical engrams become active.