HD is a rare, adult-onset, autosomal dominant, progressive neurodegenerative disease. George Huntington (Figure 1) was the first person to provide a comprehensive description of adult-onset HD in ...

UCLA Health researchers say study findings uncover Huntington's disease mechanisms and pave new ways to develop treatments.

Since the first description in 1872 (ref. 1) of Huntington's disease—a hereditary neurodegenerative disease characterized by progressive movement disorder, cognitive decline and psychiatric ...

Huntington's disease is one of the most common inherited ... or moderately (Msh2 and Mlh1) modify pathogenesis in HD mouse model. Interestingly, these genes together encode a minor mismatch ...

ElevateBio is seeking out partnerships for its lead gene therapy after the construct reduced the levels of a toxic protein in mice with Huntington’s disease by more than 80%. The therapy had no ...

A drug originally developed for high blood pressure could find a new use in the treatment of Huntington's disease, thanks to an artificial intelligence-based drug discovery programme at Spain's ...