The tricarboxylic acid (TCA) cycle is a pivotal source for mitochondrial NADH and the core metabolic route for production of many biosynthetic precursors. Over the past 15 years, oncogenic mutations ...
Pyruvate dictates redox balance and cell size, establishing metabolism as a dominant regulator of cellular fitness, unveiling new strategies to modulate cancer, regeneration, and diabetes.
Researchers at Duke University Medical Center and Wake Forest University School of Medicine have identified ALDH4A1, a mitochondrial proline-metabolizing enzyme, as a third structural component of the ...
Transgenic Nicotiana tabacum (cv Petit Havana SR1) containing high levels of mitochondrial alternative oxidase (AOX) protein due to the introduction of a sense transgene(s) of Aox1, the nuclear gene ...
Glycolysis is the breakdown of glucose into two pyruvate molecules. This process does not require oxygen (it is anaerobic). The production of pyruvate from glucose involves the production of several ...
The citric acid cycle is also known as the Krebs cycle or the tricarboxylic acid cycle. It is a series of reactions in a closed loop that are fundamental for cellular respiration. The citric acid ...
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