Even those who maintain that super-resolution microscopy is a powerful tool of biological discovery have admitted that it may have a bit of an image problem. For example, in a recent review, several ...

To study living organisms at ever smaller length scales, scientists must devise new techniques to overcome the so-called diffraction limit. This is the intrinsic limitation on a microscope's ability ...

Example of super-resolution microscopy: The image shows how the Discrete Molecular Imaging (DMI) technology visualizes densely packed individual targets that are just 5 nanometer apart from each other ...

To unravel the complexities of biological phenomena, scientists have long relied on microscopy to visualize the intricate details of their specimens, including tissue architecture, cell morphology, ...

With the rapid revolution in super-resolution microscopy, the resolution of far-field optical microscopy has entered the sub-nanometer era, providing new insights into macromolecules in vitro and in ...

A decade ago, the Nobel Prize in Chemistry was awarded to a trio of researchers for the development of super-resolved fluorescence microscopy. The announcement at the time stated that the researchers’ ...

eDL-cSIM: An AI-driven super-resolution imaging method that captures high-quality live-cell dynamics in a single exposure, enhancing speed, resolution, and environmental robustness for advanced ...

Explore advances in protein imaging techniques and spatial proteomics. Learn how modern imaging tools reveal protein dynamics ...

The rapid evolution of microscopy techniques has transformed our ability to visualise biological structures and processes at unprecedented resolutions. Advances in live‐cell imaging, super‐resolution ...

The brain relies on real-time delivery of oxygen and nutrients through its microvasculature, which threads through neural ...

Fluorescence images of nuclei in a cell spheroid labeled by rsGamillus-S with a diameter of 100 µm observed with widefield, SPA-SIM, and 3DSIM at a depth of 43 µm. Credit: From Nature Methods (2024).