Transfer RNAs (tRNAs) deliver specific amino acids to ribosomes during translation of messenger RNA into proteins. The abundance of tRNAs can therefore have a profound impact on cell physiology, but ...

tRNA is an important component of the biological synthesis of new proteins, as it carries a specific amino acid that will be incorporated to the protein through the ribosome machinery, as directed by ...

There are different kinds of ribonucleic acids that play essential roles in many aspects of molecular biology, including the creation of proteins from gene sequences in DNA. One type of ribonucleic ...

Despite the remarkable functional diversity that can be achieved with just four bases, many RNA molecules also undergo diverse targeted chemical modifications that considerably expand the nucleotide ...

The enzymes studied are tRNA nucleotidyltransferases: enzymes that attach three nucleotide building blocks in the sequence C-C-A to small RNAs in the cell (so-called transfer RNAs) so that they can ...

Raghu R. Chivukula, MD, PhD, a physician-investigator in the Departments of Medicine & Surgery and the Center for Genomic Medicine at Massachusetts General Hospital and Harvard Medical School, is the ...

We welcome Drs Nathan Howell and Boaz Tirosh as new faculty members in the Department of Biochemistry! Dr. Howell is an Assistant Professor with research interests in tRNA modification. He is an ...