This set of experiments provides important knowledge for how the infralimbic cortex is recruited to inhibit behavior after extinction training. The evidence supporting the conclusions is convincing ...

Comprehensive residue-level mapping of amyloid-beta recognition reveals how sequence variants, post-translational ...

An efficient neural screening approach rapidly identifies circuit modules governing distinct behavioral transitions in response to pathogen exposure.

Drug repurposing analyses show that citalopram exerts anti-tumor effects by targeting C5aR1 on tumor-associated macrophages to enhance phagocytosis and CD8+ T cell immunity.

Mir195 enables Ebf1-deficient hematopoietic progenitor cells to mature into B cells, suggesting some miRNA can substitute for transcription factors in differentiation.

Experiments mapping individual neurons in the sensorimotor cortex of mice show that sharp transitions in functional properties can define cortical regions.

Small-molecule mitochondrial transcription factor A modulators stabilize mtDNA, preventing cytosolic escape and suppressing cGAS-STING interferon signaling, while improving bioenergetics and fibrosis ...

The acquisition and expression of Pavlovian conditioned responding are shown to be lawfully related to objectively specifiable temporal properties of the events the animal is learning about.

Using a similar unilateral discrimination protocol across three experiments with human adults (n = 96; 1,295 sessions), we now reveal distinct patterns of specificity, generalization, and persistence ...

The behaviour of a receptor protein can be influenced by the presence of certain lipids in the membrane it is embedded in.

Mouse primary motor and somatosensory cortices contain detailed information about the many time-varying arm and paw joint ...

A comprehensive single-cell atlas of AML uncovers regulatory networks and age-dependent molecular differences to advance the understanding of disease mechanisms and enable subtype-specific therapeutic ...