TEDC1 and TEDC2, functions in generating centriolar triplet microtubules, and that this is crucial for the proper formation of centriolar subdomains and the stability of centrioles throughout the cell ...

Myotonic dystrophy type 1 (DM1) is the most common adult-onset form of muscular dystrophy and a condition that severely ...

Structural biology is the study of the molecular structure ... which encodes the protein tau; the mutant protein forms harmful aggregates in the brain. Cryo-electron microscopy of tau filaments ...

BRCA1 and BRCA2 genes play a crucial role in repairing damaged DNA. Mutations in BRCA1 and BRCA2 substantially increase the likelihood of breast and ovarian cancer, respectively. This new research ...

Research by UMass Chan Medical School scientists Sharon Cantor, PhD, and Jenna M. Whalen, PhD, poses a new explanation for how cancer-fighting drugs attack and destroy BRCA1 and BRCA2 tumor cells.

Myotonic Dystrophy Type 1 (DM1) is the most common adult-onset form of muscular dystrophy and a condition that severely affects multiple organs including skeletal muscle, heart, brain and the ...

By inserting mutant proteins into the cells ... sequestration of LZTS2 leads to cytokinesis failure, Journal of Cell Biology (2024). DOI: 10.1083/jcb.202308124 ...

Men, superpowers aren't enough - here are the mutants who use guns, swords, playing cards and energy claws to stay one step ahead.

Certain glycans -- sugar-like compounds with carbohydrate chains -- containing galactose, may exhibit potential prebiotic properties that support human health. Identifying enzymes capable of breaking ...

A pan-mutant selective, wild-type-sparing ... Leveraging our deep expertise in biology and a world class medicinal chemistry team, we are building a diverse pipeline of novel small molecule ...