Immune cells called regulatory T cells have long been known for their role in countering inflammation. In the setting of ...

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

Explore the role of the extracellular matrix (ECM) in prostate cancer progression and discover natural therapies, including ...

EPFL researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel ...

T-cell therapy, originally developed for haematological malignancies, has recently emerged as a promising therapy for ...

Objectives SLE is a multifaceted autoimmune disorder with a complex pathogenesis involving genetic, environmental and ...

Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ...

Megakaryocytes (MKs), known for their role in platelet production, have emerged as critical players in immune responses, ...

A group of immune proteins called the inflammasome can help prevent blood stem cells from becoming malignant by removing certain receptors from their surfaces and blocking cancer gene activity, ...

Immune complexes, like the inflammasome, help protect stem cells from cancer by removing surface receptors and suppressing ...

A group of immune proteins called the inflammasome can help prevent blood stem cells from becoming malignant by removing ...

SORL1 dysfunction messes with endosomes in neurons, and with lysosomes in microglia.