Background Colorectal cancer (CRC) exhibits increased levels of arachidonic acid-derived pro-inflammatory derivatives ...

Penn Engineers have redesigned the lipid nanoparticles (LNPs) used to deliver mRNA vaccines, showing that subtle changes in lipid chemistry can influence immune cell metabolism and reduce inflammation ...

Increasing the efficiency of LNPs as therapeutic vehicles offers promise for better mRNA-based and gene editing treatment success.

Illustration of a dimer protein structure. A structure of the stimulator of interferon genes (STING) dimer shows how it binds to a phosphatidylinositol species. Credit: Nature The work suggests new ...

At the end of the experiment, one healthy broiler from each replicate, which visually approximated the average weight, was selected for blood sampling and slaughtering. Blood samples were collected ...

A pinched nerve occurs when there is pressure or force on an area of a nerve, causing it to send pain signals to the brain. Most instances are mild, and a person can often treat them at home. This ...

Joseph Clayton Schoolar, M.D., Ph.D. (1928-2013) was professor of Pharmacology and Psychiatry at Baylor College of Medicine. He was born and grew up in the Mississippi Delta. At 17 he joined the U.S.

ABSTRACT: Soil soluble organic matter is an important component in the study of carbon and nitrogen cycling in terrestrial ecosystems. Soil microorganisms, as soil decomposers, participate in soil ...

Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to ...

Proper regulation of lipid metabolism and lipid-mediated signal transduction is a major foundation of cellular homeostasis in eukaryotic cells. Derangements in these processes result in a number of ...